He has terzetto sons, Peter, Michael, and David, all of whom come actors. Dom, his sons & his married woman, actress Carol (to whom he has been married since 1965), occasionally pop up inside both others' projects.

He is for instance credited when Dom De Luise, Dom Deluise, or even Dom De Luises.

Filmography
Diary of a Bachelor (1964) Fail-Safe (1964) The Glass Bottom Boat (1966) The Busy Body (1967) ''What's So Bad About Feeling Good? (1968) The Twelve Chairs (1970) Norwood (1970) Who Is Harry Kellerman and Why Is He Saying Those Terrible Things About Me? (1971) Every Little Crook and Nanny (1972) Blazing Saddles (1974) The Adventures of Sherlock Holmes' Smarter Brother (1975) Silent Movie (1976) The World's Greatest Lover (1977) Sextette (1978) The End (1978) The Cheap Detective (1978) The Muppet Movie (1979) (Cameo) Hot Stuff (1979) (also director) The Last Married Couple in America (1980) Fatso (1980) Wholly Moses (1980) Smokey and the Bandit Part II (1980) History of the World: Part I (1981) The Cannonball Run (1981) Peter-No-Tail (1981) (voice in English dubbed version) The Secret of NIMH (1982) (voice) The Best Little Whorehouse in Texas (1982) Cannonball Run II (1984) Johnny Dangerously (1984) Haunted Honeymoon (1986) An American Tail (1986) (voice) A Taxi Driver in New York (1987) Spaceballs (1987) (voice only) Going Bananas (1988) Oliver & Company (1988) (voice) The Princess and the Dwarf (1989) All Dogs Go to Heaven (1989) (voice) Loose Cannons (1990) Driving Me Crazy (1991) An American Tail: Fievel Goes West (1991) (voice) Munchie (1992) (voice only) The Magic Voyage (1992) (voice) Almost Pregnant (1992) The Skateboard Kid (1993) (voice only) Happily Ever After (1993) (voice) Robin Hood: Men in Tights (1993) The Silence of the Hams (1994) A Troll in Central Park (1994) (voice) Red Line (1996) All Dogs Go to Heaven 2 (1996) (voice) Boys Will Be Boys (1997) The Good Bad Guys (1997) Between the Sheets (1998) (Cameo) The Godson (1998) Baby Geniuses (1999) Lion of Oz (2000) (voice) The Braniacs.com (2000) It's All About You (2001) Always Greener (2001) My X-Girlfriend's Wedding Reception (2001) Remembering Mario (2003) (voice only) Girl Play (2004) Breaking the Fifth (2004) Bongee Bear and the Kingdom of Rhythm (2006) (voice) (currently inside pre-production)

TV Work
The Entertainers (1964-1965) The Dean Martin Show (regular performer from either 1972-1973) The Dean Martin Summer Show (regular performer within 1966) The Dom DeLuise Show (1968) (canceled after Fin months) The Glen Campbell Goodtime Hour (regular performer from either 1971-1972) Roman Holidays (1972) (canceled after Quaternary months) Losta Luck (1973-1974) Only with Married Men (1974) Happy (1983) (also executive producer) The Dom DeLuise Show (1987-1988) Die Laughing (1990) Timmy's Gift: A Precious Moments Christmas (1991) (voice) Fievel's American Tails (1991-1992) (voice) Candid Camera (host from either 1991-1992) The Ren & Stimpy Show (cast member from 1993-1995) (voice) Burke's Law (1994-1995) Don't Drink the Water (1994) Tin Soldier (1995) Shari's Passover Surprise (1996) All Dogs Go to Heaven: the Series (1996-1999) (voice) The Charlie Horse Music Pizza'' (1998-1999)